Are you seeking comprehensive information about Low-Dose Naltrexone (aka LDN)? Have you been prescribed this medication by your doctor and wish to gain a better understanding of it? You’re in the right place. Understanding certain drugs and their purposes can be challenging at times. This guide is here to address some of the fundamental questions about low-dose naltrexone. 

Keep reading to discover four key aspects of LDN, including how it works and its potential uses for various health conditions. 

1. What is Low-Dose Naltrexone?

Naltrexone was synthesized in the 1960s as an orally administered opioid antagonist. It has been traditionally employed for treating opioid and alcohol addictions. In recent times, a low-dose form, known as LDN, has gained attention for its potential use in addressing various health issues like pain, inflammation, immune problems, and conditions related to the gut, brain, and mental health, including cancer. Yet, it’s important to note that there’s limited scientific research supporting these claims.

2. What Are The Benefits of LDN?

LDN may offer a range of notable benefits, which include the following:

Pain Management

Low-dose naltrexone holds significant promise in the field of pain management. LDN’s mechanism of action stimulates the body’s natural pain relievers, endorphins. By enhancing the release of endorphins, LDN may assist individuals in better managing chronic pain. This is especially advantageous for conditions that may be difficult to address with standard pain medications, such as:

  • Fibromyalgia
  • Neuropathic pain
  • Chronic pain


LDN is commonly available as a generic medication, often more budget-friendly than brand-name drugs. Furthermore, LDN is prescribed in very low doses, contributing to its cost-effectiveness. This affordability makes it an accessible choice for patients with limited budgets.

But how much does LDN cost? It’s important to have this conversation with your healthcare provider and pharmacist. They can offer specific details about pricing in your region, potential insurance coverage, and any available assistance programs.

Immune System Regulation

LDN’s ability to modulate the immune system is particularly valuable in autoimmune disorders, where the immune system mistakenly attacks the body’s own tissues. Potential benefits include:

  • Multiple Sclerosis (MS): LDN has the potential to reduce symptoms and slow the progression of this autoimmune neurological disorder.
  • Rheumatoid Arthritis: LDN may reduce swelling and alleviate symptoms of inflammatory joint conditions.
  • Hashimoto’s Thyroiditis: LDN may help regulate the immune response in individuals with this autoimmune thyroid condition.

Anti-Inflammatory Effects

Low-dose naltrexone might potentially have anti-inflammatory effects because it appears to affect microglial cells. These cells are thought to be important in causing overall body and nerve inflammation. When these microglial cells become active, they seem to produce things like pro-inflammatory cytokines, free radicals (reactive oxygen species), and nitric oxide. These substances are thought to be associated with feelings of pain, inflammation, fatigue, and feeling under the weather.


LDN’s neuroprotective properties make it a promising option for managing neurodegenerative diseases such as Alzheimer’s, which involve the gradual degeneration of nerve cells in the brain and nervous system.

LDN may alleviate symptoms and slow the loss of motor function. Moreover, the neuroprotection provided by LDN may delay the debilitating consequences of the disease, enhancing an individual’s cognitive abilities and overall well-being.

Potential for Long COVID Relief

Low-Dose Naltrexone is under consideration as a possible treatment for long COVID symptoms. LDN appears to partially block specific brain receptors, which may stimulate the release of endorphins — natural molecules produced by our bodies to alleviate pain. This quality of LDN has demonstrated potential in assisting long COVID patients who experience flu-like aches and pains, as documented by National Geographic earlier this year.

However, it is important to note that the University of British Columbia is carrying out a clinical trial to check if low-dose naltrexone can help people with long COVID in the long term. They’re planning more trials to understand which patients will benefit the most from it and why, and also to figure out the best dose to use.

Safety and Other Considerations

Although LDN is believed to be well-tolerated, larger, well-organized clinical trials are necessary to figure out when it is safe and works well for different conditions before it can be suggested.

Before using low-dose naltrexone, individuals should consult their doctors, especially pregnant women. While LDN has potential benefits for various medical conditions, seeking medical advice is essential. Physicians can assess a patient’s specific needs, consider potential interactions with other medications, and provide guidance on dosage and monitoring. 

Pregnant women, in particular, should be cautious, as the effects of LDN during pregnancy are not well-established. Consulting a doctor ensures that treatment decisions are informed, safe, and aligned with each individual’s unique medical history and requirements.

3. Are There Any Side Effects?

Due to the extremely low dosage, side effects with low-dose naltrexone are rare. It’s important to note that low-dose naltrexone is unlikely to cause the same side effects as its higher-dose counterpart. Potential low-dose naltrexone side effects may include:

  • Insomnia or difficulty sleeping
  • Nausea
  • Constipation
  • Vivid dreams

4. How to Take LDN?

LDN is commonly administered orally in either liquid form or as a capsule. The dosage can vary depending on the patient and the specific condition being treated. Low doses (1–5 mg) of Naltrexone, according to an analysis published on the National Center for Biotechnology Information, may be used to help treat conditions such as fibromyalgia, multiple sclerosis, Crohn’s disease, cancer, and complex-regional pain syndrome.

In Conclusion

Low-dose naltrexone (LDN) is a medication with a unique mechanism of action that may be beneficial for various medical conditions. It has generated increasing interest in the medical community and among individuals seeking alternative or complementary therapies because of its ability to modulate the immune system, boost endorphin production, and reduce inflammation.

However, it’s crucial to use LDN with caution and under the supervision of a healthcare provider, as the appropriate dosage and treatment plan may vary depending on the patient and their individual circumstances. While LDN shows promising potential, further research is needed to confirm its effectiveness and safety for various purposes.


Leave A Reply